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The Week of Nightmares had the Ravnos founder Zapathasura wake up and start raining death and destruction.
Real After All: Obviously the Antediluvians eventually turn out to be very real. Physical God: The most powerful vampires aside from Caine, they all possess the capability to use ten-dot Disciplines suitably named Plot Device. The Tzimisce Antediluvian, however, has no name because no sound on Earth could make the alien tones that are its name. Some of them are just so old their names have been lost to time. The Nameless: Often, an Antediluvian is not referred to by a name, just the name of their clan in square brackets.
For turning against and killing the Second Generation, Caine cursed each of them with a curse that would become each clan's signature flaw.
Monster Progenitor: Clan Progenitor, rather.
For example, the Eldest is obliterated by the power of God.
Laser-Guided Karma: Many of the Antediluvians get this. Horror Hunger: The Antediluvians have been vampires for so long the only part of being alive they remember is being hungry.